Here, you can find topic-related background literature as well as dissemination activities of the REPO-TRIAL consortium itself. Once new publications are available, we will list them here, including links to the full text version or journal repository.

• REPO-TRIAL Consortium (2020). Publishable Summary of the 1st Research Period (1st January 2019 – 30th April 2020). (PDF | 116 KB)
• Adamo L, Yu J, Rocha-Resende C et al. (2020). Proteomic Signatures of Heart Failure in Relation to Left Ventricular Ejection Fraction. Journal of the American College of Cardiology. Volume 76(17): pages 1982-94.
• Mucke H. (2020). COVID-19 and the Drug Repurposing Tsunami. ASSAY and Drug Development Technologies. Volume 18(5): pages 211-214.
• Schmidt H.H.H.W. (2020). La network medicine sarà una vera rivoluzione per la nostra salute [article in Italian]. Corriere della Sera. (23 January 2020)
• Mucke H. (2019). An Answerable Challenge. European Biopharmaceutical Review. July 2019: pages 14-17.
• Enzym hemmt Zusammenbruch der Blut-Hirn-Schranke nach Schlaganfall [article in German] (2019). Ärzteblatt. News/102842 (7 May 2019)
• Casas AI, Hassan AA, Larsen SJ et al. (2019). From single drug targets to synergistic network pharmacology in ischemic stroke. PNAS. Volume 116: pages 7129-7136.
• Casas AI, Kleikers PWM, Geuss E et al. (2019). Calcium-dependent blood-brain barrier breakdown by NOX5 limits postreperfusion benefit in stroke. J Clin Invest. Volume 130: pages 1772-1778.
• Larsen SJ, Röttger R, Schmidt HHHW, Baumbach J. (2019). E. coli gene regulatory networks are inconsistent with gene expression data. Nucleic Acids Res. Volume 47: pages 85-92.
• Elbatreek MH, Pachado MP, Cuadrado A, Jandeleit-Dahm K, Schmidt HHHW. (2019). Reactive Oxygen Comes of Age: Mechanism-Based Therapy of Diabetic End-Organ Damage. Trends Endocrinol Metab. Volume 30: pages 312-327.
• Aguirre-Plans J, Piñero J, Menche J, Sanz F, Furlong LI, Schmidt HHHW, Oliva B, Guney E. (2018). Proximal Pathway Enrichment Analysis for Targeting Comorbid Diseases via Network Endopharmacology. Pharmaceuticals. Volume 11(3): page 61.
• REPO-TRIAL Project. (5/31/18). Press Release: REPO-TRIAL – A European Union Project for in silico Trial-Based Drug Repurposing. Maastricht.
• Schmidt HHHW, Baumbach J, Loscalzo J et al. (2018). Expert Panel Discusses the Importance of Systems Medicine. Systems Medicine. Volume 1 (1): pages 3-8.
• Cuadrado A, Manda G, Hassan A et al. (2018). Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach. Pharmacol Rev. Volume 70 (2): pages 348-383.
• Langhauser F, Casas AI, Dao VTV et al. (2018). A diseasome cluster-based drug repurposing of soluble guanylate cyclase activators from smooth muscle relaxation to direct neuroprotection. NPJ Syst Biol Appl. Volume 4, online first: pages 1-13.