UMC Utrecht

Heidelberglaan 100
3584 CX Utrecht
THE NETHERLANDS

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Team Leader

Prof. Dr. Timothy Radstake

Principal Investigator

Phone: +31 88 755 054 9

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Team Staff

Abhinandan Devaprasad

PhD Student

Phone: +31 88 755 326 5

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Institute presentation

UMC Utrecht believes that everyone deserves the best possible healthcare. We constantly improve our knowledge together with patients, patient organizations and partners in healthcare, research and industry. Our doctors, researchers and students join forces to solve major medical issues. Patients at UMC Utrecht receive treatment specifically geared to their individual needs.

In the group of Prof. Dr. Radstake, our goal is to provide better and more affordable healthcare for patients with chronic inflammatory diseases, and to better understand the underlying molecular pathways. Despite extensive research over the past years, still approximately 90% of our drugs fail in more than 60% of the patients with chronic inflammation. Hence, there is a great unmet need to better understand these conditions and develop effective therapies. In other words: to know who to treat with what and for how long: so-called personalized medicine.

We apply a Systems Medicine approach to identify those molecular pathways that cause chronic inflammatory diseases, and to enable disease interception, prediction of mode of action, prognosis, and therapy response. Within our Systems Medicine approach we focus on isolated immune cell subsets to which we apply multiple OMICS layers. Afterwards, computational modelling is used to integrate these extensive data sets. Molecular candidates arising from the Systems approach are then taken further in Proof-of-Concept and Proof-of-Mechanism studies using ex vivo experimentation, “disease in a dish” models and experimental models of inflammation.