The training programme section offers interesting educational articles for everyone interested in any of the scientific fields of REPO-TRIAL. Click here to also watch our REPO-TRIAL Videos.

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• Zeinab M. Mamdouh et al. (2023). Why the way we define diseases prevents innovation and precision medicine.

This paper explains why our current disease definitions and their heterogenous use in different disciplines prevent the flow of information from genetics to the clinic and basic science and back. It is a motivation to harmonise disease definitions and eventually overcome them by mechanism-based ones.

• Alexandra Petraina et al. (2022). Cyclic GMP modulating drugs in cardiovascular diseases: mechanism-based network pharmacology.

This paper describes how construct and apply disease mechanisms as protein-protein interaction or signalling modules in an unbiased manner. 

• Cristian Nogales et al. (2022). Network pharmacology: curing causal mechanisms instead of treating symptoms.

This review describes how protein-protein interaction or signalling modules can be exploited for diagnosis and mechanism-based therapy by network pharmacology.

• Harald H. H. W. Schmidt and Jörg Menche (2022). The regulatory network architecture of cardiometabolic diseases.

This editorial explains the application of in-silico trial and network medicine methods to mechanistically redefine diseases currently labeled as cardio-metabolic. 

• Sepideh Sadegh et al. (2021). Network medicine for disease module identification and drug repurposing with the NeDRex platform.

There was an unmet need for adaptable tools allowing biomedical researchers to employ network-based drug repurposing approaches for their individual use cases. This paper and tool closed this gap with NeDRex, an integrative and interactive platform for network-based drug repurposing and disease module discovery. NeDRex integrates ten different data sources covering genes, drugs, drug targets, disease annotations, and their relationships. NeDRex allows for constructing heterogeneous biological networks, mining them for disease modules, prioritizing drugs targeting disease mechanisms, and statistical validation. The utility of NeDRex is demonstrated in five use-cases.

• Harald H. H. W. Schmidt, Pietro Ghezzi and Antonio Cuadrado (2021). Reactive Oxygen Species – Network Pharmacology and Therapeutic Applications.

This book redefines oxidative stress as a physiological signalling mechanism, that can be dysregulated, explained by network pharmacology.

• Edwin K. Silverman et al. (2020). Molecular networks in Network Medicine: Development and applications.

This review discusses Molecular Networks (types of data, analytical methods, ways to validate them). Categorizing diseases by organs or symptoms is the past – deciphering disease mechanisms is the future!

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