This section keeps you updated on any major developments throughout the course of the REPO-TRIAL project.
Identification of drug repurposing candidates for treatment of Covid-19
In order to find out which existing drugs might be suitable for the treatment of Covid-19, numerous research groups from all over the world are working on systems medicine approaches. A research team from the Chair of Experimental Bioinformatics (ExBio) at the TUM School of Life Sciences of the Technical University of Munich (TUM) has now developed the first online data analysis platform (CoVex) for this purpose:
The Coronavirus Explorer (CoVex) integrates the virus-human interactome for SARS-CoV-2 and SARS-CoV. CoVex is designed to help provide a comprehensive understanding of the infection mechanisms and focuses not only on the virus and its direct interaction partners, but in particular involves the host-protein interaction network.
Click here for more details or pictures…
…or just watch or new video on YouTube:
Conference canceled due to COVID-19! –Final COST action OpenMultiMed Conference on Multiscale Systems and Network Medicine
Our main objective is to gather a critical mass of researchers and stakeholders from different disciplines and coordinate these researchers as a team to define, investigate important S&T challenges in multiscale systems medicine and to improve existing and develop novel solutions for multiscale systems medicine.
International Conference on Systems and Network Medicine
18 – 19 March 2020
TranslaTUM, Technischen Universität München
Einsteinstraße 25, 81675 Munich, Germany
Dr. Ana I Casas, one of the WP leader of the REPO-TRIAL consortium, recently gave a talk at the 51st Brazilian Congress of Pharmacology and Experimental Therapeutics (SBFTE) in Maceió, State of Alagoas, the Northeast Region of Brazil. The scientific program covered a wide range of topics in the frontier of pharmacological knowledge. This year the theme of the Meeting was Challenging frontiers in Pharmacology.
REPO-TRIAL Coordinator Prof. Harald H.H.W. Schmidt and Jan Baumbach, member of the REPO-TRIAL consortium were keynote speakers at the First International Conference in Systems and Network Medicine: Applications of Systems Science and Thinking to Biomedicine (Georgetown University, 11-13 September 2019). The conference aims to create an active engagement between participants, encourage future interdisciplinary research opportunities, create collaboration amongst the international systems thinking stakeholders, and foster networking.
4th SC Meeting held in Luxembourg: The REPO-TRIAL consortium was meeting in Luxembourg to discuss the overall progress and first emerging results!
Check out our brand new project video on YouTube!
REPO-TRIAL’s scientific coordinator, clinician, and pharmacologist Prof. Dr. Harald Schmidt, the bioinformatics expert and co-coordinator Prof. Dr. Jan Baumbach, the regulatory expert Dr. Hermann Mucke, and Priv.-Doz. Dr. Benedikt Frank, the neurologist overseeing the stroke study, explain the details of the project during an interview session prior to the 2nd GA Meeting in Vienna, Austria, on March 4th, 2019. We also prepared a German version of the video, see Our Findings.
REPO-TRIAL Coordinator Prof. Harald H.H.W. Schmidt talked about “Symptom- to mechanism-based concepts in medical research, practice and teaching” at the forum ‘Science & Health’ in Fürstenfeldbruck, Germany.
Existing drugs fail to provide benefit for most patients. The efficacy of drug discovery is in a constant decline. This poor translational success of biomedical research is due to false incentives, lack of quality/reproducibility and publication bias. The most important reason, however, is our current concept of disease, i.e. mostly by organ or symptom, not by a mechanism. Systems Medicine will lead to a mechanism-based redefinition of disease, precision diagnosis, and precision therapy – eliminating the need for drug discovery, and completely reorganizing how we teach, train and practice medicine.
A new study by Dr. Kleinschnitz, Prof. Dr. Harald Schmidt and REPO-TRIAL colleagues with the title “Calcium-dependent blood-brain barrier breakdown by NOX5 limits postreperfusion benefit in stroke” has recently been published in the Journal of Clinical Investigation! In May, this study has been covered in form of a separate article in the news section of the Ärzteblatt (renowned German magazine for medical doctors). Congratulations!
2nd GA Meeting held in Vienna: The EU-funded project is now in its 2nd year & brings experts from systems biology, biochemistry, in silico modelling, neurology and cardiology to one table to tackle complex, mechanistically related diseases! From 4-6 March, the REPO-TRIAL group met in Vienna to discuss the next steps of the project.
REPO-TRIAL Coordinator Dr. Harald H.H.W. Schmidt gave a talk at the World Government Summit in Dubai. View the full presentation on “The End of Medicine as we know it”on YouTube!
Harald Schmidt and Jan Baumbach were keynote speakers at the International Conference on Bioinformatics and Biomedicine (Madrid, 3-6 December 2018).
E. coli gene regulatory networks are inconsistent with gene expression data
This publication, co-authored by Profs. Harald Schmidt and Jan Baumbach and to be published in Nucleic Acids Research, challenges established knowledge of the systemic biology on the cellular level, finding no system-wide correlation between the expression of transcription factors and their target genes in E. coli. More sophisticated network models are needed, with higher complexity and more dynamic features, to truly understand how gene expression is regulated. The preprint version of the paper can be accessed here.
Harald Schmidt and Jan Baumbach were keynote speakers at the International Congress on Precision Medicine Beyond Cancer
This September Coordinator Professor Dr. Harald Schmidt will give a talk on “Disease Cluster-based Drug Repurposing” at the International Conference on Network Medicine and Big Data in Rome
We have barely started our 5-year project and are already busy promoting our science! Ana Casas Guijarro (UM) and Hermann Mucke will hold presentations at the 7th Drug Repositioning, Repurposing and Rescue Conference in Chicago.
The REPO-TRIAL Kick-off Meeting took place in Innsbruck (Austria), 20-23 February 2018, and was a full success! A big thanks to all attendees!
Four different advisory boards, consisting of experts for each topic, will ensure scientific quality, efficient data management and data analysis, as well as adherence to ethical standards, clinical trial regulations, and diversity requirements.